Abcam, ab102086, Anti-QKI antibody

Size: 50µL
Rabbit Polyclonal QKI antibody. Suitable for IHC-Fr, ICC/IF, WB, IHC-P and reacts with Mouse, Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human QKI aa 150 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:IHC-P, ICC/IF, IHC-Fr, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human QKI aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q96PU8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The QKI protein also known as Quaking is an RNA-binding protein belonging to the STAR (Signal Transduction and Activation of RNA) family. It plays an important role in RNA metabolism including the regulation of alternative splicing RNA stability and translation. QKI with a molecular mass of approximately 38 kDa is widely expressed in mammals especially in the central nervous system and the heart. Its presence in various tissues highlights its broad biological relevance and necessity in maintaining cellular function.
Biological function summary
QKI functions in regulating mRNA which is essential for proper cell differentiation and development. This protein is not known to be part of a larger complex but interacts with various RNA substrates and auxiliary proteins to exert its functions. QKI's actions impact neural tissue development and lipid metabolism by modulating the splicing of target RNA molecules. It also influences myelination in the nervous system by controlling key mRNAs involved in the process.
Pathways
QKI plays key roles in two important signaling pathways: the Wnt/β-catenin and the AKT signaling pathways. In the Wnt pathway QKI modulates gene expression by influencing mRNA transcripts involved in cell fate and proliferation. Through its participation in AKT signaling QKI links to proteins like PI3K and mTOR essential for cell survival and growth. These pathways illustrate QKI’s influence in both neural and systemic biological processes.
QKI is linked to neurodevelopmental disorders and schizophrenia. Abnormal expression or mutations in QKI can lead to neurological dysfunction highlighting its significance in brain health. Schizophrenia associations involve dysregulation of QKI's RNA targets that affect synaptic functioning. Additionally QKI's interactions with proteins such as hnRNP K and KHDRBS1 show the interconnected nature of its role in these complex conditions.