Abcam, ab10306, Anti-Mu Opioid Receptor splice variant antibody

Size: 50µL
Rabbit Polyclonal Mu Opioid Receptor antibody. Suitable for IHC-Fr and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Rat Oprm1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat,
Applications:IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Rat Oprm1. The exact immunogen used to generate this antibody is proprietary information.P33535

Product details:
The powerful effects of opiate are mediated through the opioid receptors located on the plasma membrane of neurons and other peripheral cells. There are at least 3 types of opioid receptors, mu, kappa, and delta, each with a distinct pharmacologic profile. The mu opioid receptor is the primary site of action for the most commonly used opioids, including morphine, heroin, fentanyl, and methadone.

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-Preservative: 0.05% Sodium azideConstituents: Whole serum, Shipped at conditions-Blue Ice, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Mu Opioid Receptor splice variant often called MOR or OPRM1 is a G protein-coupled receptor with a molecular mass of approximately 47 kDa. It acts as a binding site for endogenous opioids such as endorphins and exogenous substances like morphine. Located abundantly in the central nervous system particularly in the brain and spinal cord the MOR plays a critical role in modulating pain perception. Its expression also extends to peripheral sites like the gastrointestinal tract which can influence various physiological processes.
Biological function summary
The Mu Opioid Receptor splice variant regulates analgesia reward and addictive behaviors. This receptor forms part of larger signaling complexes that include G proteins and beta-arrestins which mediate its signaling and regulatory effects. When opioids bind to MOR the receptor undergoes a conformational change that activates intracellular signaling cascades resulting in decreased neuronal excitability and neurotransmitter release which underlie its analgesic properties.
Pathways
The Mu Opioid Receptor splice variant participates in the opioid signaling and reward pathways. The opioid signaling pathway involves key interactions with proteins like G-protein subunits and adenylate cyclase leading to the inhibition of cyclic AMP production. In the reward pathway MOR engages with the mesolimbic system involving interactions with dopamine D2 receptors which influence addictive behaviors and the experience of pleasure.
The Mu Opioid Receptor splice variant is closely linked to addiction and chronic pain conditions. Addiction to opioids often results from the receptor's role in the reward pathway while chronic pain conditions relate to its activity in sensory pathways. MOR's interaction with proteins like delta opioid receptors and nociceptin receptors influences the development and progression of these disorders making it a critical target for therapeutic strategies aimed at modulating opioid effects while reducing side effects.