Abcam, ab103160, Anti-RAB32 antibody

Size: 100µg
Rabbit Polyclonal RAB32 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Ras-related protein Rab-32.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human Ras-related protein Rab-32.Q13637

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RAB32 is a member of the RAB protein family involved in intracellular membrane trafficking. It is sometimes called Ras-related protein RAB32. The molecular mass of RAB32 is about 26 kilodaltons. It locates itself primarily in the cytoplasm and various organelles such as the mitochondria and endosomes. RAB32 has a role in vesicle trafficking acting as a molecular switch that toggles between active GTP-bound and inactive GDP-bound states managing the transport and fusion of cellular vesicles.
Biological function summary
The normal function of RAB32 influences several cellular processes including pigmentation and energy metabolism. It does not usually act alone but is part of larger protein complexes that regulate intracellular processes. RAB32 contributes to mitochondrial fission and fusion as well as melanosome biogenesis. Its interaction with other proteins helps establish a cellular environment compatible with various organelle functions.
Pathways
Its role is significant in key cellular pathways like the cAMP signaling pathway and the autophagy-lysosome pathway. RAB32 interacts with proteins such as PKA and ATG16L1 to modulate these pathways. In the cAMP pathway RAB32 affects protein kinase A activity modifying cellular responses to external signals. In the autophagy process it assists in lysosome function contributing to cellular cleanup and energy homeostasis.
The dysfunction of RAB32 has connections with some types of cancer and neurodegenerative diseases. Its overexpression or aberrant regulation is often seen in melanoma development where it can disrupt normal pigmentation processes. Additionally in neurodegenerative conditions like Alzheimer's disease RAB32 dysregulation might influence mitochondrial dynamics as it interacts with proteins like DRP1. Understanding these connections provides potential targets for therapeutic interventions in these diseases.