Abcam, ab103527, Anti-Wwp2 antibody

Size: 100µg
Rabbit Polyclonal WWP2 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 21 publications. Immunogen corresponding to Synthetic Peptide within Human WWP2 aa 200-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human WWP2 aa 200-250. The exact immunogen used to generate this antibody is proprietary information.O00308

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Wwp2 also known as WWP2 or ubiquitin protein ligase E3 component N-terminal homolog 2 is a member of the NEDD4-like E3 ubiquitin ligases. It has a molecular weight of approximately 104 kDa. This protein facilitates the attachment of ubiquitin molecules to substrate proteins tagging them for proteasomal degradation or for regulation of their activity localization or interactions. Wwp2 is expressed in various tissues with higher expression in lung heart muscle and kidney indicating a broad functional range.
Biological function summary
Wwp2 plays a critical role in cellular processes like growth division and differentiation by regulating the stability of key signaling proteins. It functions as part of protein complexes that include WW domain-containing proteins which enables it to interact with multiple substrates. Through its ubiquitination activity Wwp2 influences pathways involved in the maintenance of cellular homeostasis and response to stimuli.
Pathways
Wwp2 has significant involvement in the TGF-beta signaling pathway and the Wnt signaling pathway. In the TGF-beta pathway Wwp2 mediates the degradation of SMAD2 and SMAD7 which are central to the regulation of this signaling cascade. Wwp2 also interacts with proteins like SMURF2 and RNF11 within these pathways promoting fine-tuned control of signal transduction ultimately influencing development and differentiation processes.
Wwp2 is linked to conditions such as cancer and cardiac hypertrophy. Dysregulation of Wwp2 can lead to aberrations in the TGF-beta pathway contributing to oncogenic processes and proliferation of tumor cells. Additionally Wwp2's role in the Wnt pathway associates it with cardiac hypertrophy where altered signaling may disturb cardiac muscle cell growth and function. Noteworthy Wwp2's interaction with proteins like SMAD7 in these contexts offers further insight into its pathological relevance.