Abcam, ab103976, Anti-Munc18-2 antibody

Size: 50µL
Rabbit Polyclonal Munc18-2 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human STXBP2 aa 300-550.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human STXBP2 aa 300-550. The exact immunogen used to generate this antibody is proprietary information.Q15833

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Munc18-2 also known as Syntaxin-binding protein 2 is a 65 kDa protein that plays a role in vesicle transport machinery. It interacts with syntaxins to regulate the docking and fusion of vesicles with their target membranes. Munc18-2 is mainly expressed in hematopoietic cells where it facilitates regulated secretion.
Biological function summary
This protein facilitates the formation of secretory vesicle complexes. Munc18-2 is a part of the SNARE complex working synergistically with other components to ensure efficient vesicular transport and release. In immune cells this supports processes such as the exocytosis of lytic granules and cytokine release essential for immune response functions.
Pathways
Munc18-2 plays a role in the exocytosis and vesicular fusion pathways. It is closely associated with the SNARE proteins like VAMPs (vesicle-associated membrane proteins) and SNAPs (synaptosomal-associated proteins). In the immune system it is part of the machinery that mediates the transport and release pathways of granules and other vesicular contents.
Munc18-2 dysfunction is linked to familial hemophagocytic lymphohistiocytosis (FHL). This condition involves defective immune response due to hindered vesicular secretion leading to uncontrolled inflammation. Munc18-2 mutations affect the interaction with syntaxin 11 a SNARE protein which disturbs immune cell function contributing to the pathogenesis of this disorder.