Abcam, ab104223, Anti-TDP43 antibody [3H8]

Size: 50µL
Anti-TDP43 antibody [3H8] (ab104223) is a mouse monoclonal antibody detecting TDP43 in Western Blot, Flow Cytometry, ICC/IF . Suitable for Human, Mouse, Rat . - KO validated for confirmed specificity - Over 10 publications
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:3H8,
Isotype:IgG1,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:Flow Cyt, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human TARDBP.Q13148

Product details:
Product Specifications
Anti-TDP43 antibody [3H8] (ab104223) is a mouse monoclonal antibody and is validated for use in Flow Cyt, ICC/IF, WB in human, mouse and rat samples.
Anti-TDP43 antibody [3H8] (ab104223) specifically detects TDP43 (UniProt ID: Q13148; Molecular weight: 45kDa) and is sold in 50µL selling sizes.
Quality and Validation
Abcam's high quality validation processes ensure Anti-TDP43 antibody [3H8] (ab104223) has high sensitivity and specificity.
The specificity of Anti-TDP43 antibody [3H8] (ab104223) has been confirmed by testing in knockout samples.
Anti-TDP43 antibody [3H8] (ab104223) has been cited over 18 times in peer reviewed journals and is trusted by the scientific community.
Related Products
Conjugation-ready, carrier free format available for antibody clone 3H8 -
ab60704

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-Preservative: 0.03% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TDP43 also known as TAR DNA-binding protein 43 is a protein of approximately 43 kDa. It plays a role in various cellular processes primarily by binding to DNA and RNA. Researchers find TDP43 expressed mainly in neuronal tissues but it is present in other cell types as well. Known for its involvement in regulating gene expression and mRNA stability TDP43 interacts with other proteins within the nuclear compartment. The full function and activities of TDP43 are still under exploration but its importance in normal cellular functions is well recognized.
Biological function summary
TDP43 acts as a regulator of RNA splicing and transcription by forming ribonucleoprotein complexes. The protein can bind to specific sequences in RNA helping in the proper processing and transport of mRNA. Furthermore TDP43 has a role in stress granule formation a cell response to stress. Researchers have identified that the protein undergoes various post-translational modifications which could influence its behavior and function within the cellular environment.
Pathways
Several important pathways include TDP43 due to its functions in RNA metabolism. This protein contributes to the spliceosomal cycle and other pathways involved in mRNA processing. TDP43 interacts with proteins such as FUS and hnRNP which are also involved in RNA splicing and are essential for maintaining mRNA integrity. These relations make TDP43 an important player in regulating gene expression and protein synthesis.
The association of TDP43 with neurodegenerative diseases is significant. Its abnormal aggregation is linked to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). In these diseases TDP43 forms insoluble inclusions within neurons and glial cells. This mislocalization and aggregation can disrupt normal cellular function leading to cell death. In the context of ALS TDP43 often associates with proteins like SOD1 which are implicated in disease pathogenesis highlighting its role in neurodegeneration.