Abcam, ab104450, Anti-CEACAM1 + CEACAM3 + CEACAM6 antibody [YTH71.3]

Size: 50µg
Rat Recombinant Monoclonal CEAM1 antibody. Suitable for IHC-P, WB, IHC-Fr, ICC/IF, Flow Cyt and reacts with Human, Recombinant fragment - Human samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing CEACAM1 protein.
Key facts
Host species:Rat,
Clonality:Monoclonal,
Clone number:YTH71.3,
Isotype:IgG2a,
Carrier free:No,
Reacts with:Human,
Applications:WB, Flow Cyt, IHC-Fr, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Cell preparation containing CEACAM1 protein. The exact immunogen used to generate this antibody is proprietary information.P13688,
Specificity:Recognizes Human CEACAM1. CEACAM1 is expressed by Human neutrophils and cells in some cases of colon carcinoma. Reacts with transfectants containing BGPa, NCA and CGM1a which are CEA subfamily members.

Product details:
The production method has been switched from hybridoma to recombinant on 06th June 2025.
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CEACAM1 CEACAM3 and CEACAM6 are part of the carcinoembryonic antigen-related cell adhesion molecule family. CEACAM1 also known as CD66a has a mass of approximately 75 kDa. These proteins mainly localize to epithelial endothelial and certain immune cells. CEACAM1 and CEACAM6 participate in cell-cell adhesion while CEACAM3 functions more in immune cell response primarily by recognition and clearance of bacteria.
Biological function summary
These proteins serve different roles that impact cellular behavior. CEACAM1 can regulate cell signaling and immune response. It exists in complex forms that influence cell adhesion and signaling. CEACAM3 mainly appears in granulocytes playing a role in phagocytosis of bacteria. CEACAM6 is involved in modulating cell proliferation and invasion. Their involvement in immune regulation and cellular communication highlights their biological importance in maintaining normal tissue function and immune surveillance.
Pathways
These proteins are part of the immune response and cell adhesion pathways. CEACAM1 influences the lymphocyte activation pathway related with proteins like SHP-1 and SHP-2 that modulate signaling cascades. CEACAM3 is linked with the phagocytic pathway which involves interactions with other opsonin receptors. These pathways contribute to managing cellular response to external stimuli and maintaining homeostasis.
These targets are linked with cancer development and inflammatory bowel disease. Overexpression of CEACAM1 and CEACAM6 occurs often in cancers such as colorectal and lung cancer where their abnormal regulation can lead to increased cell proliferation and metastasis. CEACAM3's role in immune response connects it with inflammatory conditions where faulty recognition or clearance mechanisms may arise. Understanding these proteins' roles in pathological conditions offers insights into potential therapeutic interventions and diagnostic markers.