Abcam, ab105458, Anti-Talin 2 antibody [68E7]

Size: 50µg
Mouse Monoclonal Talin 2 antibody. Suitable for IP, ELISA, WB, ICC/IF, IHC-Fr and reacts with Mouse samples. Cited in 12 publications. Immunogen corresponding to Recombinant Fragment Protein within Mouse Tln2 aa 450-950.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:68E7,
Isotype:IgG2b,
Carrier free:No,
Reacts with:Mouse,
Applications:IP, ICC/IF, IHC-Fr, WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Mouse Tln2 aa 450-950. The exact immunogen used to generate this antibody is proprietary information.Q71LX4

Product details:
Growth Conditions: RPMI1650 + Glu + Pen + Strep + 10% FCS @ 37°C + 5%CO2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Talin 2 also known as TLN2 is a large cytoskeletal protein approximately 270 kDa in mass. It acts mechanically as an important player in linking integrins to the actin cytoskeleton supporting the structural integrity of cells. Talin 2 is expressed in various tissues including muscle and neuronal systems with expression patterns similar to Talin 1 but has distinct roles in cellular adhesion and signal transduction.
Biological function summary
Talin 2 plays a significant role in cell adhesion and migration processes. It is part of a complex that includes integrins and other cytoskeletal proteins facilitating the transmission of mechanical signals across the cell membrane. This protein aids in focal adhesion assembly ensuring proper cellular responses to external stimuli. Talin 2 contributes to stabilizing intracellular interactions which are essential for maintaining tissue structure and cell motility.
Pathways
Talin 2 is deeply embedded in integrin-mediated signaling and the cytoskeletal organization pathway. It modulates interactions between integrins and F-actin orchestrating actin dynamics and contributing to cellular adherence junctions. Talin 2 functions closely with proteins like vinculin which supports actin filament linkage and reinforces mechanical stability under tension.
Talin 2 has been linked to muscular dystrophies and certain neuropathies. Mutations or dysregulation in Talin 2 can impair muscle function as its interaction with dystrophin is critical for muscle integrity. Additionally disruptions in Talin 2 mediated signaling could contribute to neurodegenerative disorders where its interactions with integrins can affect neuronal connectivity and survival. Understanding Talin 2's role in these conditions may provide insights for therapeutic interventions.