Abcam, ab106251, Anti-HOPX/HOD antibody

Size: 100µg
Rabbit Polyclonal HOPX/HOD antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human HOPX.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human HOPX.Q9BPY8

Properties and Storage Information:
Form-Lyophilized, Reconstitution-Reconstitute in 200 µL of water, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: 1% BSA, 0.184% Tris glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein HOPX also known as Homeodomain only protein is encoded by the HOPX gene. It is a small protein with a mass of approximately 8.5 kDa. HOPX is expressed in various tissues including cardiac myocytes epithelial tissues and stem cells. Known for its homeodomain-like structure HOPX does not bind DNA directly. Instead it influences transcription by interacting with other transcription factors and cofactors. The alternate name for HOPX is HOD and it serves as a reliable marker reflecting cellular differentiation and development.
Biological function summary
HOPX plays a role in regulating cell differentiation and tissue homeostasis. It acts without forming part of a larger protein complex primarily serving as a transcriptional regulator. This protein modulates the expression of genes critical for cell differentiation particularly in muscle and cardiac tissues. HOPX negatively regulates cell proliferation by modifying the transcription machinery influencing how cells enter mature states. Its role in differentiation makes it significant in both embryonic development and maintaining the integrity of adult cells.
Pathways
HOPX is significantly involved in the Wnt signaling pathway an important pathway in regulating cell fate across developmental stages. It modulates this pathway by interacting with proteins like β-catenin ensuring proper differentiation of various cell types. Another relevant pathway that includes HOPX is the BMP signaling pathway. Through this pathway HOPX contributes to osteogenesis and chondrogenesis working alongside proteins like SMADs which are effectors in the BMP pathway.
HOPX has implications in cancer and heart disease. Aberrant HOPX expression can lead to cancer progression particularly in lung and colon cancers. It seems to act as a tumor suppressor and its interactions with proteins like p53 highlight its role in cancer biology. Additionally HOPX's regulation in cardiac development links it to congenital heart defects when mutations or misregulation occur. Understanding HOPX's interactions in these contexts offers potential therapeutic insights.