Abcam, ab106570, Anti-ZIP-12 antibody

Size: 100µg
Rabbit Polyclonal ZIP-12 antibody. Suitable for ICC, WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human SLC39A12.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse,
Applications:ICC/IF, IHC-P, ICC, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SLC39A12. The exact immunogen used to generate this antibody is proprietary information.Q504Y0,
Specificity:At least four isoforms of ZIP-12 are known to exist. ab106570 is predicted not to cross-react with other SLC39 family members.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-Up to 12 months, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The ZIP-12 protein also known as SLC39A12 functions as a zinc transporter regulating zinc homeostasis by importing zinc into cells. This protein weighs approximately 42 kDa and is expressed primarily in the brain with notable presence in neurons. Its role ensures proper zinc levels inside cells which is critical for various cellular functions including enzyme activity and gene expression.
Biological function summary
ZIP-12 facilitates the transportation of zinc an essential trace element into neural cells. It operates as part of the ZIP family of zinc transporters working closely with other family members to maintain zinc balance within the cell. Proper zinc levels are important for neuronal signaling and overall brain health influencing cognitive functions and development.
Pathways
ZIP-12 integrates into important signaling networks such as the MAPK and PI3K-Akt pathways. These pathways important for cell differentiation and proliferation rely on zinc availability to function correctly. ZIP-12’s activity affects proteins like Akt and ERK connecting it to cellular survival and growth mechanisms.
ZIP-12 displays associations with neurological conditions including schizophrenia and Alzheimer's disease. Zinc imbalance influenced by ZIP-12 malfunction leads to disrupted neuronal functions contributing to disease pathology. Proteins like Tau and amyloid-beta within these diseases further intersect with ZIP-12 via shared pathways influencing neuronal health.