Abcam, ab106624, Anti-ZMYM2/RAMP antibody

Size: 100µg
Rabbit Polyclonal ZMYM2/RAMP antibody. Suitable for WB and reacts with Mouse samples. Cited in 6 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:At least three isoforms of ZMYM2/RAMP are known to exist; ab106624 will detect only the longest isoform. It is predicted to not cross react with other ZMYM protein family members.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-Up to 12 months, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZMYM2/RAMP also referred to as zinc finger MYM-type protein 2 or Retinoic Acid Modulating Protein mechanically functions as a transcriptional regulator. It has a molecular mass of about 150 kDa and predominantly localizes in the nucleus. The protein is expressed in various tissues with notable presentations in the brain and testis. It forms part of intricate multiprotein complexes which facilitate its function in regulating gene transcription.
Biological function summary
ZMYM2/RAMP influences several cellular functions through its role as a co-regulator of transcription. It notably participates in corepressor complexes like the NuRD complex which modulates chromatin structure and gene expression. This protein's MYM-type zinc fingers bind specifically to DNA or protein partners allowing it to alter expression profiles of genes involved in diverse cellular processes including cell differentiation and development.
Pathways
ZMYM2/RAMP features within several important biological signaling routes including the retinoic acid signaling pathway. This pathway which ZMYM2/RAMP helps regulate is important for development and differentiation. Within this pathway ZMYM2/RAMP interacts with other proteins such as retinoic acid receptors to modulate transcriptional responses. Additionally it connects with the Wnt signaling pathway intersecting at points with well-recognized proteins like β-catenin playing further roles in cell fate determination.
ZMYM2/RAMP exhibits connections to specific cancers and developmental abnormalities. Aberrant expression or mutations in ZMYM2/RAMP have associations with acute promyelocytic leukemia particularly through its fusion with the RARα gene interfering with normal cellular differentiation. Furthermore it shows relevance to certain nervous system disorders through its interaction with proteins involved in neural development marking it as a potential target for understanding and tackling related pathologies.