Abcam, ab106646, Anti-ZSCAN4 antibody

Size: 100µg
Rabbit Polyclonal ZSCAN4 antibody. Suitable for WB and reacts with Mouse samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human ZSCAN4.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ZSCAN4. The exact immunogen used to generate this antibody is proprietary information.Q8NAM6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZSCAN4 also known as Zinc finger and SCAN domain-containing protein 4 plays a mechanical role in telomere maintenance and genomic stability. It has a molecular mass of approximately 55 kDa. Scientists observe ZSCAN4 expression mainly in embryonic stem cells and germ cells. The protein contains a SCAN domain and several zinc finger motifs that facilitate its binding to specific DNA sequences playing an important role in telomere elongation and genomic stability.
Biological function summary
ZSCAN4 connects to mechanisms vital for proper chromosome segregation and DNA repair. It also participates in the amplification of telomere repeats a process key for maintaining telomere length. ZSCAN4 can associate with complexes involved in chromatin remodeling and genomic reprogramming. Its function proves essential for the self-renewal and differentiation of pluripotent stem cells aiding the long-term maintenance of telomere integrity.
Pathways
ZSCAN4 integrates into the telomere extension and genomic stabilization pathways. Telomerase-related protein complexes interact with ZSCAN4 promoting telomere lengthening which slows down aging processes in cells. Additionally ZSCAN4 connects with the DNA repair machinery pathways that function to fix DNA damage and maintain genome integrity. Collaboration with proteins like TERT (Telomerase Reverse Transcriptase) and those in the SIRT (Sirtuin) family emphasize its cooperation in telomere biology and genomic stability.
ZSCAN4 has implications in cancer and age-related pathologies. Abnormal activation or suppression of ZSCAN4 leads to chromosomal instability a factor linked to cancer progression. In specific cancer types ZSCAN4 helps in bypassing senescence promoting indefinite cell proliferation. Furthermore researchers link ZSCAN4 activity to age-related disorders due to its role in telomere dynamics. In these contexts abnormalities in ZSCAN4 function often involve partnerships with proteins such as TERT and p53 which are key to telomere biology and tumor suppression.