Abcam, ab106719, Anti-TMEM184C antibody

Size: 100µg
Rabbit Polyclonal TMEM184C antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TMEM184C.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TMEM184C. The exact immunogen used to generate this antibody is proprietary information.Q9NVA4,
Specificity:ab106719 predicted to not crossreact with other members of the TMEM184 protein family.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-Up to 12 months, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TMEM184C also known as Transmembrane Protein 184C is a membrane protein involved in cellular transport mechanisms. It has a molecular mass of approximately 37.5 kDa. Researchers observe its expression across different tissues including brain heart and skeletal muscle indicating its diverse functional roles. The protein's presence in varied tissues suggests its involvement in broad physiological processes.
Biological function summary
TMEM184C modulates key mechanisms involved in cellular transport and signaling pathways. It participates in facilitating communication between cellular compartments. TMEM184C does not generally associate with large protein complexes emphasizing its role as a more independent functional unit. The protein contributes to maintaining cellular homeostasis through modulation of signaling proteins and transporters.
Pathways
TMEM184C plays a role in maintaining cellular signaling integrity and nutrient transport. It demonstrates connections with the MAPK/ERK signaling pathway influencing cellular response to external stimuli. TMEM184C associates with proteins in this pathway such as ERK to regulate processes related to cell survival and proliferation. Its involvement in the PI3K-Akt pathway also suggests a role in regulating cell growth and glucose metabolism.
TMEM184C associates with certain neurological disorders and metabolic syndromes. Dysfunction or altered expression of TMEM184C could influence diseases like Alzheimer's due to its role in neural signaling pathways. Additionally metabolic conditions like type 2 diabetes may be linked to TMEM184C via its participation in the PI3K-Akt pathway and regulation of insulin signaling proteins. These associations highlight the importance of TMEM184C in maintaining normal physiological function and its potential as a therapeutic target.