Abcam, ab108341, Anti-Androgen Receptor antibody [ER179(2)] - ChIP Grade

Size: 100µL / 1mL
Anti-Androgen Receptor antibody [ER179(2)] - ChIP Grade (ab108341) is a rabbit monoclonal antibody detecting Androgen Receptor in Western Blot, IP, IHC-P, ICC/IF, ChIP . Suitable for Human, Mouse, Rat . - Biophysical QC for unrivalled batch-batch consistency - Over 70 publications
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:ER179(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ICC/IF, ChIC/CUT&RUN-seq, IHC-P, ChIP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Anti-Androgen Receptor antibody [ER179(2)] - ChIP Grade (ab108341) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in ChIC/CUT&RUN-seq, ChIP, ICC/IF, IHC-P, WB in human, mouse, rat samples.
Anti-Androgen Receptor antibody [ER179(2)] - ChIP Grade (ab108341) has been cited over 79 times in peer reviewed journals and is trusted by the scientific community.
Abcams high quality manufacturing and validation processes ensure Anti-Androgen Receptor antibody [ER179(2)] - ChIP Grade (ab108341) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility.
Anti-Androgen Receptor antibody [ER179(2)] - ChIP Grade (ab108341) has 4 independent reviews from customers.
Anti-Androgen Receptor antibody [ER179(2)] - ChIP Grade (ab108341) specifically detects Androgen Receptor (UniProt ID: P10275; Molecular weight: 99kDa) and is sold in 100 uL and 1 mL selling sizes.
Conjugation-ready, carrier free format available for antibody clone ER179(2) -
ab212175
Antibody clone ER179(2) is also available pre-conjugated to a variety of labels for your convenience - HRP, Alexa Fluor® 647, Alexa Fluor® 488, Alexa Fluor® 594 (
ab22352
ab22432
ab2269
, ab26358).
The androgen receptor (AR)/DHTR plays a crucial role in the development and progression of various cancers, including breast cancer and prostate cancer. Utilizing our highly-validated AR antibody, can significantly enhance the detection and study of AR expression. Research indicates that AR is a promising therapeutic target for treating hormone-dependent cancers, offering potential for improved patient outcomes. Validated also for CUT&RUN, which is a key applications to map protein-DNA interactions on a genome-wide scale using NGS.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The androgen receptor (AR) also known as NR3C4 functions mechanically as a type of nuclear receptor that is activated by binding androgens including testosterone and dihydrotestosterone. The AR has a molecular weight of approximately 110 kDa. It is expressed in various tissues notably in the prostate skeletal muscle and certain areas of the brain. Within cells AR is usually located in the cytoplasm when unbound and translocates to the nucleus upon activation by its ligands.
Biological function summary
AR interacts with androgen hormones to regulate gene expression. It forms a complex with coactivators and corepressors to modulate transcription of target genes involved in male sexual development and reproductive function. AR plays an important role in the development and maintenance of male characteristics and reproductive activity. Its expression impacts cellular processes such as proliferation differentiation and apoptosis.
Pathways
AR is intricately involved in the androgen signaling pathway which affects the regulation of genes related to male sexual characteristics. It also plays a part in the PI3K/Akt pathway influencing cell growth and survival. The AR pathway interacts with proteins such as estrogen receptors to mediate cross-talk between hormonal pathways highlighting its broad biological impacts.
AR has a significant connection to prostate cancer where it drives tumor growth and progression. Mutations and overexpression of the androgen receptor are often observed in prostate cancer cells. Another condition linked to AR is androgen insensitivity syndrome where mutations in the AR gene result in partial or complete inability of cells to respond to androgenic hormones. In these conditions AR antagonists like bicalutamide are often used as treatment inhibiting the receptor's activity to manage disease progression.