Abcam, ab108422, Anti-FOXA2 antibody [EPR4466]

Size: 100µL / 1mL
Anti-FOXA2 antibody [EPR4466] (ab108422) is a rabbit monoclonal antibody detecting FOXA2 in Western Blot, IHC-P, ICC/IF . Suitable for Human, Mouse . - Clone EPR4466 is the most cited clone to FOXA2 - Biophysical QC for unrivalled batch-batch consistency - Over 100 publications
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR4466,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Anti-FOXA2 antibody [EPR4466] (ab108422) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in ICC/IF, IHC-P, WB in human, mouse samples.
Anti-FOXA2 antibody [EPR4466] (ab108422) has been cited over 104 times in peer reviewed journals and is trusted by the scientific community.
Abcams high quality manufacturing and validation processes ensure Anti-FOXA2 antibody [EPR4466] (ab108422) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility.
Anti-FOXA2 antibody [EPR4466] (ab108422) has 11 independent reviews from customers.
Anti-FOXA2 antibody [EPR4466] (ab108422) specifically detects FOXA2 (UniProt ID: Q9Y261; Molecular weight: 48kDa) and is sold in 100 uL and 1 mL selling sizes.
Conjugation-ready, carrier free format available for antibody clone EPR4466 -
ab2281
Antibody clone EPR4466 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488, Alexa Fluor® 647, HRP, Alexa Fluor® 594, Alexa Fluor® 568, Alexa Fluor® 555, Alexa Fluor® 75 (
ab193864
ab193879
ab19388
ab311752
ab31332
ab313233
ab3292
FOXA2 is a pivotal transcription factor involved in the regulation of liver development and lung development. Research has shown that FOXA2 plays a significant role in various cancers, including liver and lung cancers. Understanding FOXA2's function can provide insights into developmental biology and potential therapeutic targets for cancer treatment.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FOXA2 also known as HNF3B is a transcription factor that plays a significant role in gene regulation. This protein has a mass of approximately 47 kDa and is expressed in various tissues including the liver pancreas and lung. Researchers detect FOXA2 using techniques like ELISA for protein quantification. Its function involves regulating the expression of genes critical for development and metabolism.
Biological function summary
FOXA2 influences important processes in embryonic development and organogenesis. It does not typically act as part of a larger complex but independently binds to DNA enabling the transcription of target genes. FOXA2 affects liver function by regulating genes involved in glucose and lipid metabolism and it also plays a part in the differentiation of cells in development stages.
Pathways
FOXA2 operates within pathways like the insulin signaling pathway and the Wnt signaling pathway. It collaborates with other transcription factors like FOXA1 and FOXA3 to maintain metabolic homeostasis. In the Wnt pathway FOXA2 impacts cell fate decisions essential for embryonic patterning and development.
Alterations in FOXA2 expression have connections to conditions such as diabetes and liver diseases. Changes in FOXA2 expression could disrupt liver metabolism leading to metabolic disorders. Moreover FOXA2 ties to the regulation of other proteins like PDX1 in the context of diabetes where it plays a role in insulin biosynthesis and pancreatic cell function.