Abcam, ab110647, Anti-OCM2 antibody [EPR5310]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal OCM2 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR5310,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
OCM2 also known as Oncomodulin 2 is a calcium-binding protein with a molecular mass of approximately 12 kDa. It belongs to the family of EF-hand proteins and is part of the wider calmodulin group. OCM2 shows expression mainly in the retina and cochlea indicating its role in sensory functions. This protein is essential for calcium ion homeostasis requiring accurate localization to exert its functions in physiological conditions.
Biological function summary
Oncomodulin 2 plays a role in regulating intracellular calcium levels which affects various cellular processes. It does not appear to function as part of a known complex. Its expression in sensory areas like the retina and cochlea suggests involvement in signal transduction pathways related to visual and auditory functions. By modulating calcium ions OCM2 supports neuronal specificity and survival indicating a potential role in the development and maintenance of sensory tissues.
Pathways
OCM2 contributes to calcium signaling pathways that are important for cellular communication and regulation. It interacts with proteins such as calmodulin and troponin C which are integral to calcium signal transduction. These pathways relay messages important for cellular adaptation to environmental changes and for the maintenance of cellular homeostasis. The protein's ability to bind calcium supports mechanistic activities within these pathways.
Variations or dysfunction of OCM2 associate with sensory impairments such as retinal degeneration and certain forms of hearing loss. Studies indicate a connection to proteins like Nrl and Myo7a within these conditions. Such associations highlight the potential for OCM2 as a biomarker or therapeutic target in treating sensory-related disorders. The disease links reinforce the understanding of OCM2’s role in sensory organ function and pathogenesis.