Abcam, ab110767, Anti-SLC44A1/CTL1 antibody

Size: 100µg
Rabbit Polyclonal SLC44A1/CTL1 antibody. Suitable for WB and reacts with Human samples. Cited in 13 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The target SLC44A1 also known as CTL1 is a member of the choline transporter-like family. This protein is essential for transporting choline across cell membranes. As a membrane protein it is involved in the uptake of choline a necessary precursor for the synthesis of phosphatidylcholine and acetylcholine. CTL1 has a molecular mass of approximately 70 kDa. It is expressed in various tissues including the brain liver and kidneys highlighting its importance across multiple biological systems.
Biological function summary
SLC44A1 plays a significant role in the synthesis of membrane phospholipids. It does not act alone; it forms part of a complex system involving other transporter proteins to ensure efficient choline uptake and utilization. By facilitating choline transport CTL1 supports the production of important lipids for cell membrane integrity and neurotransmission contributing to processes important for cellular communication and function.
Pathways
SLC44A1 impacts significant metabolic pathways such as the Kennedy pathway responsible for phosphatidylcholine biosynthesis. Its activity is closely associated with enzymes like choline kinase and phosphocholine cytidylyltransferase which further facilitate phospholipid biosynthesis. This pathway integration highlights its role in maintaining membrane structure and signaling functions.
SLC44A1 has implications in neurological conditions such as Alzheimer’s disease and certain types of cancer. In Alzheimer's impaired choline transport can lead to deficits in acetylcholine a neurotransmitter necessary for memory and learning. Moreover aberrant expression of CTL1 is linked with oncogenic processes in liver cancer. In these cases its interaction with proteins associated with choline metabolism and cellular growth indicates potential mechanisms underlying disease pathogenesis.