Abcam, ab111169, Anti-GPCR GPR116 antibody

Size: 100µg
Rabbit Polyclonal GPCR GPR116 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human ADGRF5 aa 600-700.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ADGRF5 aa 600-700. The exact immunogen used to generate this antibody is proprietary information.Q8IZF2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab111169 was affinity-purified from Rabbit antiserum by affinity-chromatography using epitope-specific immunogen., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GPCR GPR116 also known as adhesion G protein-coupled receptor F5 is a receptor protein that belongs to the large family of adhesion GPCRs. The GPR116 protein has an approximate mass of 140 kDa. It plays a role in regulating G protein signaling and interacts with other cellular proteins through its extracellular and intracellular domains. GPR116 is expressed in multiple tissues with high expression levels noted in endothelial cells lungs and adipose tissue.
Biological function summary
This receptor is involved in important processes like maintaining pulmonary surfactant homeostasis and regulating vascular integrity. GPR116 does not function alone but as part of larger receptor complexes interacting with various other proteins and molecules at the cellular membrane. Its activity influences the balance of signals within the cell impacting cellular responses and activities.
Pathways
GPR116 is an important component in the surfactant and vascular maintenance pathways. It is associated with the phosphatidylinositol signaling system and can influence phospholipase C activity. GPR116 also interacts with other proteins like thrombin which assists in mediating inflammatory responses via G protein-coupled signal transduction.
Dysfunction of GPR116 has implications in respiratory conditions like pulmonary alveolar proteinosis and cardiovascular diseases such as hypertension. In these disease contexts GPR116's relationship with proteins like surfactant protein A and B shows its role in regulating respiratory and cardiovascular conditions. Understanding these interactions might offer insights into targeting GPR116 for therapeutic interventions.