Abcam, ab112563, Anti-ATAD3B antibody

Size: 100µg
Rabbit Polyclonal ATAD3B antibody. Suitable for ICC, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ATAD3B.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ATAD3B. The exact immunogen used to generate this antibody is proprietary information.Q5T9A4,
Specificity:ab112563 is predicted to not cross-react with other ATAD protein family members.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ATAD3B also known as ATPase family AAA domain-containing protein 3B is a mitochondrial membrane protein with a mass of about 67 kDa. You can find ATAD3B expression predominantly in tissues with high energy demands including the brain and muscle. The protein functions mechanically as an ATPase enzyme involved in mitochondrial processes like maintaining mitochondrial DNA and dynamics.
Biological function summary
ATAD3B plays roles in mitochondrial homeostasis and organelle communication. It forms part of a complex machinery within the mitochondria working closely with proteins like ATAD3A. This interaction contributes to the proper arrangement of mitochondrial DNA and protein import ensuring cellular energy management and metabolic functioning remain efficient.
Pathways
ATAD3B contributes to mitochondrial biogenesis and dynamics. It integrates into pathways such as the mitochondrial quality control pathway and mitochondrial fission and fusion processes. Proteins like DRP1 and MFN2 interact with ATAD3B in these pathways influencing the balance and architectural function of the mitochondria within cells.
ATAD3B has links to neurological diseases and certain cancers. Disruptions in the function of ATAD3B correlate with altered mitochondrial dynamics seen in these conditions. Proteins such as ATAD3A and mutations in genes associated with the protein may exacerbate mitochondrial dysfunction emphasizing the importance of proper ATAD3B function in disease prevention and processes.