Abcam, ab113203, Anti-CBF1 interacting corepressor/CIR1 antibody

Size: 100µg
Rabbit Polyclonal CBF1 interacting corepressor/CIR1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human CIR1 aa 400 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CIR1 aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q86X95

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99.91% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CBF1 interacting corepressor also known as CIR1 is a coregulator that interacts with CBF1 an important transcriptional repressor. CIR1 forms a complex with CBF1 and other components to modulate transcriptional repression processes. The molecular mass of CIR1 is approximately 47 kDa. It expresses in various tissues throughout the body including the brain and lymphoid tissues. This broad expression pattern suggests a role in multiple cellular processes. CIR1 plays a central part in controlling gene expression by interacting with CBF1 and other transcriptional modulators.
Biological function summary
CIR1 serves as a mediator in transcriptional repression and is a part of the transducin-like enhancer of split (TLE) corepressor complex. This complex influences the activity of CBF1 by promoting chromatin modifications that lead to transcriptional repression. CIR1 contributes to finely regulating gene expression essential for maintaining cellular homeostasis. The TLE complex generally recruits CIR1 to target genes modulating the expression of genes involved in cell growth and differentiation.
Pathways
CIR1 modulates Notch signaling and Hedgehog pathways two critical signal transduction systems for cell fate determination and development. In the Notch signaling pathway CIR1 collaborates with CBF1 (also known as RBPJ or CSL) to repress target gene transcription until the pathway is activated. Interaction with Notch proteins results in pathway activation which is important for cell communication and differentiation. CIR1 indirectly affects the Hedgehog signaling pathway by influencing transcription factors that respond to this pathway highlighting its role in developmental processes and tumorigenesis.
CIR1 is associated with oncogenesis and neurological disorders. Dysregulation of Notch signaling involving CIR1 can contribute to various cancers by altering cell proliferation and apoptosis. In neurological conditions such as Alzheimer's disease CIR1's involvement in transcriptional repression may affect neuronal function by disrupting gene regulation. CIR1 also interacts with Presenilin proteins which are linked to Alzheimer's pathology indicating potential roles in disease progression. Understanding CIR1's function in these pathways can provide insights into therapeutic targets for related disorders.