Abcam, ab113420, Anti-FRMPD4 antibody

Size: 50µg
Rabbit Polyclonal FRMPD4 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human FRMPD4 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human FRMPD4 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q14CM0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FRMPD4 also known as FERM and PDZ domain containing 4 is a protein that is involved in the formation of cellular junctions. It weighs approximately 134 kDa. This protein shows expression in the brain kidney and heart with higher levels particularly in the cerebral cortex. FRMPD4 has a significant role in normal neuronal functioning. The PDZ domains in FRMPD4 enable interaction with the membrane-associated proteins and scaffold its integration to specific cell parts.
Biological function summary
FRMPD4 plays a role in synaptic communication and signal transduction. It participates as a component of a multi-protein complex which is essential for maintaining synaptic integrity and proper neuronal signaling. This complex involvement helps facilitate communication between neurons and supports synaptic plasticity which is critical for learning and memory functions.
Pathways
This protein is integral in synaptic plasticity and cell adhesion pathways. FRMPD4 interacts with proteins such as GRIP1 involved in glutamate receptor trafficking during synaptic function and facilitates receptor stability and localization. The presence of FRMPD4 in these pathways ensures that neurons respond correctly to synaptic inputs and maintain proper communication with adjacent cells.
Alterations in FRMPD4 expression or function associate with autism spectrum disorders (ASD) and intellectual disability. FRMPD4 abnormalities could disturb its interaction with GRIP1 influencing synaptic signaling and cognitive abilities. The potential link of this protein with these disorders suggests that it might serve as a target for therapeutic interventions aimed at correcting the synaptic dysfunction underlying these conditions.