Abcam, ab113424, Anti-FOXI3 antibody

Size: 200µL
Goat Polyclonal FOXI3 antibody. Suitable for WB and reacts with Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Mouse Foxi3 aa 200-300.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Mouse Foxi3 aa 200-300. The exact immunogen used to generate this antibody is proprietary information.D3Z120

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab113424 was purified from Goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 99% Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The target protein FOXI3 also known as Forkhead box protein I3 functions as a transcription factor involved in regulating gene expression. It has a mass of approximately 43 kDa. FOXI3 is mainly expressed in tissues derived from the ectoderm such as skin hair follicles and tooth buds. This expression pattern suggests a role in the development and differentiation of these tissues.
Biological function summary
The FOXI3 protein plays a central role in the development of ectodermal structures. It does not form part of a larger protein complex but operates by binding to DNA and controlling the expression of genes necessary for the development and morphogenesis of hair and dental structures. Its regulation of these developmental processes highlights its importance in proper ectodermal tissue function.
Pathways
The FOXI3 protein participates in the WNT signaling pathway which is important for cell differentiation and proliferation in ectodermal tissues. It also interacts with other transcription factors such as Lef1 to regulate hair follicle development. The interplay between FOXI3 and these proteins highlights its involvement in pathways that determine ectodermal tissue fate.
Genetic mutations in FOXI3 have been linked to ectodermal dysplasia a condition characterized by abnormal development of the skin hair and teeth. Research has shown that mutations can disrupt its usual function leading to these developmental issues. Additionally FOXI3 shows a connection with the protein MSX1 which also influences tooth development further implicating its role in dental disorders.