Abcam, ab113425, Anti-ING4 antibody

Size: 100µg
Rabbit Polyclonal ING4 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ING4 aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ING4 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q9UNL4

Properties and Storage Information:
Form-Lyophilized, Reconstitution-Reconstitute in 200 µL of water, Purification technique-Affinity purification Immunogen, Purification notes-ab113425 is purified by a protein affinity column., Storage buffer-pH: 7.2 Preservative: 0.02% Sodium azide Constituents: 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ING4 also known as Inhibitor of Growth Family Member 4 is a nuclear protein with a molecular mass of approximately 29 kDa. This protein mainly localizes to the nucleus and is expressed in various tissues including the brain and liver. ING4 contains a plant homeodomain (PHD) finger motif which suggests its involvement in chromatin-mediated transcriptional regulation. As a regulator of gene expression ING4 influences cell growth and apoptosis by interacting with histones to affect chromatin structure and function.
Biological function summary
The ING4 protein plays a significant role in tumor suppression. It forms part of a larger protein complex by associating with components like the nucleosome remodeling and histone deacetylase (NuRD) complex. By binding to specific histone modifications ING4 influences transcriptional regulation of several genes that control cell cycle and apoptosis. This activity helps maintain genomic stability and prevent cellular transformation establishing ING4 as a guardian against oncogenic processes.
Pathways
ING4 integrates into cellular machinery that governs the NF-κB signaling pathway and the p53 pathway. These pathways are critical for controlling inflammation and cellular stress responses. Within the NF-κB pathway ING4 interacts with proteins such as IκBα modulating inflammatory cytokine production. In the context of the p53 pathway ING4 acts together with p53 enhancing its tumor suppressor functions through transcriptional activation of p53-responsive genes.
ING4 has a notable association with cancer particularly glioblastoma and breast cancer. Reduced expression or alterations in ING4 have been linked to these malignancies where it functions to suppress the aggressive characteristics of tumor cells. ING4 also connects with proteins like HIF-1α in pathways that regulate cellular responses to hypoxia further implicating its role in tumor biology. Understanding ING4's interactions and effects offers potential for developing therapeutic strategies targeting cancer progression.