Abcam, ab114357, Recombinant Human FPRL1/RFP protein

Size: 10µg
Recombinant Human FPRL1/RFP protein is a Human Fragment protein, in the 163 to 205 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WB, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P25090,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.3% Glutathione

Product details:
This product was previously labelled as FPRL1.

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FPRL1 known also as FPR2 or formyl peptide receptor-like 1 is a G-protein-coupled receptor with an approximate mass of 39 kDa. This receptor primarily resides on the surface of immune cells such as neutrophils monocytes and dendritic cells. FPRL1 plays an important role in transmitting chemotactic signals that guide immune cells towards sites of inflammation or infection. It binds ligands that include formylated peptides and lipid mediators initiating a cascade of intracellular signals that mobilize immune responses.
Biological function summary
FPRL1 enables the immune system to detect and respond to pathogenic threats effectively. As part of the immune surveillance mechanism FPRL1 aids in the migration and function of immune cells by activating intracellular second messenger systems including calcium mobilization and MAPK pathways. Though not part of a larger protein complex it interacts closely with other signaling molecules to amplify immune responses. The receptor also shows diverse ligand recognition possibly allowing it to participate in different immune processes.
Pathways
FPRL1 holds a position in both inflammatory and resolution pathways. Notably it participates in the chemokine signaling pathway working alongside other G-protein-coupled receptors to regulate leukocyte chemotaxis. FPRL1 further involves itself in the resolution of inflammation through interactions with specialized pro-resolving mediators like lipoxins. An example of this interaction occurs with the protein ALX/FPR2 with which FPRL1 shares functional similarities contributing to both swift inflammatory responses and their resolution.
FPRL1 implicates itself in chronic inflammatory diseases and cancer. In chronic inflammatory conditions FPRL1 overstimulation may contribute to prolonged inflammation adversely affecting tissue function. Furthermore aberrant signaling through FPRL1 potentially influences tumor progression in various cancers. FPRL1 can interact with PD-L1 within the tumor microenvironment promoting immune evasion in cancer cells. Understanding these interactions offers potential therapeutic targets to modulate immune responses and treat associated disorders.