Abcam, ab115019, Anti-delta Sarcoglycan antibody

Size: 200µL
Goat Polyclonal delta Sarcoglycan antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Delta-sarcoglycan aa 200 to C-terminus.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human Delta-sarcoglycan aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q92629

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab115019 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 99% Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Delta Sarcoglycan also known as SGCD is a protein component of the sarcoglycan complex. It has an approximate mass of 35 kDa. Delta Sarcoglycan localizes predominantly in skeletal and cardiac muscle tissues. This protein forms part of a set of transmembrane glycoproteins which are integral to the muscle cell membrane. It plays an important role in maintaining the structural integrity of muscle cells by linking the sarcolemma to the extracellular matrix.
Biological function summary
Delta Sarcoglycan associates with other sarcoglycan proteins to form the sarcoglycan complex. This complex is an essential part of the dystrophin-associated glycoprotein complex (DAGC) which connects the cytoskeleton of a muscle fiber to the extracellular matrix. The proper function of this complex is essential for muscle stability during contraction and relaxation preventing damage to the muscle fibers. It interacts with dystrophin an essential adapter protein which anchors the sarcolemma to the cytoskeleton.
Pathways
Delta Sarcoglycan plays an integral role in maintaining the integrity of the dystrophin-glycoprotein complex pathway which is vital for muscle function. It also involves the adhesion and signaling pathways that influence muscle cell adhesion and communication. It shows a relationship with dystrophin where mutations in genes coding for any component including delta Sarcoglycan disrupt these pathways and affect muscle tissue integrity.
Delta Sarcoglycan mutations are primarily linked to limb-girdle muscular dystrophy type 2F (LGMD2F) and specific types of cardiomyopathy. These conditions manifest through progressive muscle weakness and deterioration emphasizing the protein’s significance in muscle health. Mutations in the dystrophin protein can exacerbate these diseases further illustrating the important synergy between dystrophin and sarcoglycan complex including delta Sarcoglycan in maintaining muscle integrity.