Abcam, ab115262, Anti-TBX18 antibody

Size: 100µg
Rabbit Polyclonal TBX18 antibody. Suitable for ICC, WB and reacts with Human samples. Cited in 14 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Replenishment batches of ab115262 are tested in WB. Previous batches were additionally validated in ICC. This application is still expected to work and is covered by our Abpromise guarantee.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TBX18 also called T-box transcription factor Tbx18 is a transcription factor involved in DNA binding and gene regulation. It has a molecular mass of approximately 60 kDa. TBX18 expresses predominantly in developing tissues including the heart kidneys and limbs. It plays a role during embryogenesis and contributes to the regulation of developmental processes by modulating the expression of other genes important for organ formation.
Biological function summary
TBX18 controls the regulation of cell differentiation and development especially in the heart and skeletal system. As a member of the T-box family of genes TBX18 participates in forming transcriptional regulation complexes. Its regulatory activities ensure that specific genes are expressed at the right time and location during developmental processes. This precise control is essential for normal embryonic development.
Pathways
TBX18 integrates into the Wnt signaling and BMP pathways which are critical for cell fate determination and organogenesis. Within these pathways TBX18 interacts with other transcription factors like Tbx5 and Pitx2 to influence heart development. Its involvement in the pathways allows it to help steer mesodermal cells towards forming specific tissues showcasing its role in guiding developmental decisions.
TBX18 has associations with congenital heart defects and limb malformations. Abnormal TBX18 expression or function can lead to structural heart anomalies with connections to other proteins like NKX2-5 and GATA4 which are also important in cardiac development. Research focuses on understanding how TBX18 mutations or dysregulation contribute to these conditions to find potential therapeutic interventions.