Abcam, ab115896, Anti-TARBP1 antibody

Size: 50µg
Rabbit Polyclonal TARBP1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TARBP1 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TARBP1 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q13395

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TARBP1 also known as RISC-loading complex subunit TARBP1 weighs approximately 314 amino acids in size. It is widely expressed in various tissues with a significant presence in the brain and other areas with high RNA activity. TARBP1 plays a mechanical role in RNA binding and processing. It influences RNA silencing pathways by interacting with specific RNA molecules which regulate gene expression. This protein modulates post-transcriptional gene silencing by forming complexes with other proteins to assist in targeting RNA molecules for degradation or translational repression.
Biological function summary
TARBP1 is involved in the RNA interference (RNAi) pathway contributing to cellular regulatory mechanisms. It associates closely with the RNA-induced silencing complex (RISC) facilitating the recognition and processing of RNA targets. This protein functions as a cofactor aiding AGO2 in cleaving target mRNA an important part of gene silencing processes within the cellular environment. These interactions are vital for maintaining cellular homeostasis and regulating various gene expression pathways through post-transcriptional modifications.
Pathways
TARBP1 is integral to the RNA-induced silencing complex loading pathway and the microRNA (miRNA) biogenesis pathway. In these pathways TARBP1 works in concert with Dicer a ribonuclease enzyme to facilitate the maturation of miRNAs which are pivotal in gene regulation. This interaction determines the gene expression patterns essential for cellular processes such as development and differentiation highlighting TARBP1’s importance in RNA silencing pathways.
TARBP1 has connections to cancer and neurodegenerative diseases. In cancer altered expression levels of TARBP1 can affect miRNA processing leading to dysregulation of genes involved in cell proliferation and apoptosis contributing to tumorigenesis. Similarly misregulation of miRNA activity influenced by TARBP1 has been observed in Alzheimer's disease where imbalanced RNA processing can lead to neuronal dysfunction. Proteins such as AGO2 and Dicer are intricately connected to these conditions as they collaborate with TARBP1 in the regulation of miRNA pathways influencing disease progression and outcomes.