Abcam, ab116438, Recombinant Human HN1 protein

Size: 10µg
Recombinant Human HN1 protein is a Human Full Length protein, in the 1 to 181 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, ELISA, WB, Mass Spec.
Key facts
Purity:>95% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:WB, Mass Spec, ELISA, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9UK76,
Animal free:No,
Carrier free:Yes,
Species:Human,
Storage buffer:pH: 7.4Constituents: PBS

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HN1 also known as Hematological and Neurological Expressed 1 protein is a small protein with a mass of approximately 10 kDa. It expresses in various tissues mainly in hematopoietic and neurological cells. Researchers also identified its expression in some cancerous tissues which suggests its potential role in tumor biology. HN1 exhibits a notable presence in cytoplasmic and nuclear compartments indicating its involvement in multiple cellular processes.
Biological function summary
Experts believe HN1 participates in cellular development and differentiation. It does not function alone but interacts with other proteins within a larger complex affecting intracellular signaling. This interaction hints at the protein's role in supporting the regulation of cellular growth and hematopoiesis. In addition HN1 influences cellular responses to stress which further supports its relevance in development and disease.
Pathways
HN1 integrates into the Jak-STAT signaling pathway and possibly the Notch signaling pathway. This association with significant signaling pathways implies its role in modulating gene expression linked to cell proliferation and differentiation. HN1 also shows interactions with other proteins in these pathways such as STAT3 suggesting collaborative involvement in regulating cellular responses to external stimuli.
Scientists have linked HN1 to cancer and neurodegenerative diseases. Its upregulation in various cancer types like breast cancer indicates a potential role in tumor cell proliferation and survival. Additionally in neurodegenerative conditions changes in HN1 expression suggest it might contribute to neuronal dysfunction. Connections to related proteins like BCL2 involved in cell survival highlight HN1’s implications in both cancer progression and neurodegenerative pathways.