Abcam, ab116892, Recombinant Human RBP3/IRBP protein

Size: 10µg
Recombinant Human RBP3/IRBP protein is a Human Fragment protein, in the 1149 to 1246 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:Tag free,
Applications:ELISA, WB, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P10745,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.3% Glutathione

Product details:
This product was previously labelled as RBP3.

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The RBP3 protein also known as Interphotoreceptor Retinoid-Binding Protein (IRBP) plays a significant mechanical role in the eye. This protein is characterized by a mass of approximately 135 kDa and is primarily expressed in the retina and vitreous body. RBP3 is involved in the transport and protection of retinoids between the photoreceptor cells and the retinal pigment epithelium. It facilitates the movement of molecules necessary for the visual cycle ensuring efficient communication between different cellular components of the eye.
Biological function summary
RBP3 is integral in maintaining retinal health aiding the regeneration of visual pigments and the function of photosensitive cells. It does not appear to be part of a larger complex but operates independently within the extracellular space between the retina cells. The protein binds retinoids including retinol and retinaldehyde which are critical for converting light into visual signals. This function supports the overall visual transduction pathway in vertebrates.
Pathways
RBP3 is an important player in the visual cycle pathway maintaining normal vision by aiding in the synthesis and recycling of visual pigments. It works closely with proteins like opsin which is involved in the photoactivation required for vision. Furthermore RBP3 interacts within the retinoid cycle in the retina ensuring that retinoids are efficiently recycled and available for phototransduction.
RBP3 has connections with retinitis pigmentosa and age-related macular degeneration both of which are severe degenerative disorders of the retina. Mutations or deficiencies in RBP3 can disrupt retinoid transport leading to impaired vision or vision loss. This protein may be linked to other visual cycle proteins such as RPE65 which also play roles in the development of these diseases. Understanding RBP3's function and interaction with other proteins helps in developing therapeutic strategies for these retinal conditions.