Abcam, ab116934, Recombinant Human ADH1B protein

Size: 10µg
Recombinant Human ADH1B protein is a Human Full Length protein, in the 1 to 375 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:Tag free,
Applications:WB, SDS-PAGE, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P00325,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.3% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The ADH1B protein also known as alcohol dehydrogenase 1B catalyzes the oxidation of alcohols to aldehydes. It plays a role in metabolic processes by enabling the conversion of ethanol to acetaldehyde. The mass of ADH1B is approximately 40 kDa. This enzyme is predominantly expressed in the liver where alcohol metabolism is an ongoing and critical function. ADH1B functions as a homodimer which means two identical subunits form the complete active enzyme.
Biological function summary
ADH1B contributes to ethanol metabolism which is important for the detoxification of alcohol in human body. The enzyme performs efficiently in metabolizing small alcohols. ADH1B does not work alone; it forms part of a larger enzyme complex. This complex also involves other alcohol dehydrogenases like ADH1A that operate in similar metabolic pathways. Together these enzymes maintain balance in alcohol and aldehyde levels in tissues.
Pathways
ADH1B is an important component of the alcohol metabolism and aldehyde metabolism pathways. It works closely with other proteins like aldehyde dehydrogenase (ALDH2) which process the acetaldehyde generated by ADH1B oxidation into acetic acid. This sequence of reactions not only aids in detoxification but also provides useful metabolic intermediates for further energy production. ADH1B interconnects with related enzymes supporting efficient regulation of metabolic flux.
The activity of ADH1B holds significance in conditions such as alcohol dependency and certain types of cancer. Genetic variations in the ADH1B gene can affect enzyme activity influencing alcohol processing speed and potential risk for addiction. Likewise altered ADH1B activity and expression levels have been linked to certain cancers particularly esophageal cancer. The relation between ADH1B and ALDH2 may also contribute to this disease risk highlighting important consequences of alcohol metabolism enzymes in human health.