Abcam, ab117787, Anti-ZFP64 antibody

Size: 100µL
Rabbit Polyclonal ZFP64 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ZFP64 aa 400-450.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ZFP64 aa 400-450. The exact immunogen used to generate this antibody is proprietary information.Q9NTW7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab117787 was affinity purified using an epitope specific to ZFP64 immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: 99% Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZFP64 also known as Zinc Finger Protein 64 acts as a transcription factor with a molecular mass of approximately 71 kDa. This protein contains multiple zinc finger domains and is highly expressed in various tissues including the brain liver and lymphoid tissues. ZFP64 regulates the transcription of target genes by binding to specific DNA sequences influencing gene expression patterns in cells.
Biological function summary
Zinc Finger Protein 64 is involved in critical cellular processes such as cell differentiation and proliferation. It contributes to gene regulation in the context of chromatin remodeling complexes but not as a direct component. ZFP64 plays significant roles in immune response modulation and neural development affecting both protein coding and non-coding regions of the genome. Research has shown its involvement in T-cell regulation and neuronal lineage determination.
Pathways
Zinc Finger Protein 64 plays an important role in the Wnt signaling pathway and the NF-kB signaling pathway. In the Wnt signaling pathway ZFP64 interacts with other proteins to control cellular processes such as growth and migration. In the NF-kB pathway ZFP64 cooperates with other transcription factors to regulate inflammatory responses and immune system activation interacting with proteins such as IKK and RelA in the process.
Research connects Zinc Finger Protein 64 to the development of autoimmune diseases and certain types of cancer such as leukemia. Alterations in ZFP64 expression or mutations may impact the regulation of immune genes leading to uncontrolled immune responses or tumor progression. The protein is also linked to aberrations in the activity of MYC in cancerous conditions influencing the cell cycle and apoptosis pathways.