Abcam, ab117837, Anti-ZNF787 antibody

Size: 100µL
Rabbit Polyclonal ZNF787 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ZNF787 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ZNF787 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q6DD87

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab117837 was affinity purified using an epitope specific to ZNF787 immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: 99% Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF787 also known as Zinc Finger Protein 787 is a protein with a molecular mass of approximately 85 kDa. This protein is part of the zinc finger protein family which is characterized by the presence of zinc finger domains. These domains allow proteins to bind nucleic acids such as DNA and RNA influencing gene expression activities. ZNF787 is expressed in various tissues but shows significant expression in certain specific tissues like the brain and liver suggesting its role in organ-specific regulatory processes.
Biological function summary
Zinc Finger Protein 787 functions as a transcriptional regulator by influencing gene expression through DNA binding. It does not operate as part of a larger complex but acts independently to exert its regulatory functions. By binding to specific DNA sequences ZNF787 can promote or inhibit the expression of multiple genes which play roles in cell differentiation and proliferation. This suggests its possible involvement in key developmental and maintenance roles within an organism.
Pathways
Zinc Finger Protein 787 plays a role in genetic regulatory networks that impact the MAPK signaling pathway and the Wnt signaling pathway. In the MAPK pathway ZNF787 potentially modulates the transcription of genes influenced by MAPK-mediated phosphorylation events impacting cellular responses like growth and apoptosis. It may also interact with proteins such as MAPK and beta-catenin in these pathways thereby linking it to important signaling events in the cell.
Zinc Finger Protein 787 has been linked to certain cancer types such as liver cancer suggesting its potential role in tumorigenesis. Aberrations in the expression or function of ZNF787 may influence the regulation of oncogenes or tumor suppressor genes impacting the progression of cancer. Additionally irregularities in ZNF787 function have been associated with neurodegenerative diseases tying it to protein interactions involved in neuronal survival and health. Understanding ZNF787's specific interactions and regulatory mechanisms could therefore provide insights into these disease pathways potentially guiding therapeutic interventions.