Abcam, ab11959, Anti-Fos B antibody [83B1138]

Size: 50µg
Anti-Fos B antibody [83B1138] (ab11959) is a mouse monoclonal antibody detecting Fos B in Western Blot, Flow Cytometry, IHC-Fr . Suitable for Human, Mouse . - Over 40 publications - Trusted since 2004
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:83B1138,
Isotype:IgG1,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-Fr, Flow Cyt, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human FOSB. The exact immunogen used to generate this antibody is proprietary information.P53539

Product details:
What is this antibody validated in?
Anti-Fos B antibody [83B1138] (ab11959) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-Fr) in Human, Mouse samples.
What is the molecular weight of Fos B?
Anti-Fos B [83B1138] (ab11959) specifically detects a band for Fos B (UniProt: P53539) at a molecular weight of 40.6kDa.
Trusted by the scientific community
Anti-Fos B [83B1138] (ab11959) was first used in a scientific publication in 2004 and has been cited over 40 times in peer-reviewed journals.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Affinity purified., Storage buffer-Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Fos B also known as FosB is a protein encoded by the FOSB gene and belongs to the Fos family of transcription factors. Weighing approximately 46 kDa this protein acts within the cell nucleus and is expressed in several tissues particularly in brain regions. Delta Fos B an isoform of Fos B has gained attention for its stable accumulation in certain neuronal populations. Researchers often study Fos B using techniques like ELISA and immunohistochemistry to investigate its presence and distribution.
Biological function summary
Functions of Fos B include regulation of gene expression through forming AP-1 transcription factor complexes with Jun family proteins. These complexes bind to DNA influencing the expression of genes involved in processes such as cell proliferation differentiation and survival. Fos B is structurally similar to other Fos family proteins such as c-Fos which emphasises its role in response to extracellular signals and stress stimuli. Both Fos B and its isoform Delta Fos B have distinct expression patterns suggesting unique functions.
Pathways
Fos B plays a role in the MAPK/ERK signaling pathway which is essential for transmitting extracellular signals to promote diverse cellular responses. Within this pathway interactions with proteins like Jun lead to modulation of gene expression critical for cellular responses to growth factors. Additionally connections to the CREB signaling pathway link Fos B to processes concerning neuronal plasticity and memory further highlighting its participation in important biological functions.
Involvement of Fos B has been noted in neurological conditions such as addiction and depression. Delta Fos B in particular accumulates in response to chronic drug exposure and serves as a molecular switch in addiction-related neuroadaptations. Connections with proteins such as CREB and other transcriptional regulators have broadened the understanding of how Fos B and its isoforms impact neural circuits and contribute to the pathology of mood disorders.