Abcam, ab120419, K252a, protein and CAM kinase inhibitor

Size: 100µg / 200µg / 1mg
MW 467.5 Da, Purity >99%. Highly potent, cell-permeable inhibitor of protein kinases such as PKA, PKC, PKG (IC 50 = 18-25 nM), Serine/threonine protein kinases (IC 50 values are 10-20 nM) and CAM kinase II (K i = 1.8 nM). Analog of staurosporine (ab120056), exhibits a wide range of effects including neuroprotection and improvement of psoriasis in vivo .
Key facts
CAS number:99533-80-9,
Purity:>99%,
Form:SolidSee storage information,
Source:Nocardiopsis sp.,
Molecular weight:467.5 Da,
Molecular formula:C27H21N3O5,
PubChem:3035817,
Nature:Native,
Solubility:Soluble in DMSO to 25 mMSoluble in ethanol to 5 mM,
Biochemical name:Antibiotic K 252a,
Biological description:Highly potent, cell-permeable inhibitor of protein kinases such as PKA, PKC, PKG (IC50 = 18-25 nM), Serine/threonine protein kinases (IC50 values are 10-20 nM) and CAM kinase II (Ki = 1.8 nM). Analog of staurosporine (ab120056), exhibits a wide range of effects including neuroprotection and improvement of psoriasis in vivo.,
Canonical smiles:CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)OC)O,
Isomeric smiles:C[C@@]12[C@](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)OC)O,
InChi:InChI=1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1,
InChiKey:KOZFSFOOLUUIGY-SOLYNIJKSA-N,
IUPAC Name:methyl (15S,16R,18R)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaene-16-carboxylate

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions|The product can be stored for up to 12 months