Abcam, ab120637, KU-55933, competitive ATM kinase inhibitor

Size: 10mg
MW 395.5 Da, Purity >99%. Potent, selective and competitive ATM kinase inhibitor. IC 50 values are 12.9 (ATM), 2000 (DNA-PK), 9300 (mTOR), 16600 (PI3K), >100000 (ATR) and >100000 nM (PI4K). Sensitizes cells to ionizing radiation and chemotherapeutics. Blocks Akt phosphorylation, induces G1 cell cycle arrest and induces apoptosis in breast and prostate cell lines.
Key facts
CAS number:587871-26-9,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:395.5 Da,
Molecular formula:C21H17NO3S2,
PubChem:5278396,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mMSoluble in ethanol to 50 mM,
Biochemical name:2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one,
Biological description:Potent, selective and competitive ATM kinase inhibitor. IC50 values are 12.9 (ATM), 2000 (DNA-PK), 9300 (mTOR), 16600 (PI3K), >100000 (ATR) and >100000 nM (PI4K). Sensitizes cells to ionizing radiation and chemotherapeutics. Blocks Akt phosphorylation, induces G1 cell cycle arrest and induces apoptosis in breast and prostate cell lines.,
Canonical smiles:C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4,
InChi:InChI=1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2,
InChiKey:XRKYMMUGXMWDAO-UHFFFAOYSA-N,
IUPAC Name:2-morpholin-4-yl-6-thianthren-1-ylpyran-4-one

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months