Abcam, ab120842, 5-Aza-2'-deoxycytidine (Decitabine), DNMT1 inhibitor

Size: 5mg / 10mg / 25mg
MW 228.21 Da, Purity >99%. Potent DNA methyltransferase 1 (DNMT1) inhibitor (IC 50 = 0.2 μM). Incorporated into DNA, inhibits DNMT1 activity to induce DNA hypomethylation. Interferes with protein synthesis. Shows antimetabolic and anticancer activities in vitro . Active in vivo .
Key facts
CAS number:2353-33-5,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:228.21 Da,
Molecular formula:C8H12N4O4,
PubChem:451668,
Nature:Synthetic,
Solubility:Soluble in water to 50 mMSoluble in DMSO to 50 mM,
Biochemical name:Decitabine,
Biological description:Potent DNA methyltransferase 1 (DNMT1) inhibitor (IC50 = 0.2 μM). Incorporated into DNA, inhibits DNMT1 activity to induce DNA hypomethylation. Interferes with protein synthesis. Shows antimetabolic and anticancer activities in vitro. Active in vivo.,
Canonical smiles:C1C(C(OC1N2C=NC(=NC2=O)N)CO)O,
Isomeric smiles:C1[C@@H]([C@H](O[C@H]1N2C=NC(=NC2=O)N)CO)O,
InChi:InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1,
InChiKey:XAUDJQYHKZQPEU-KVQBGUIXSA-N,
IUPAC Name:4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months