Abcam, ab120885, PIT-1, PIP3/protein binding inhibitor

Size: 10mg / 50mg
MW 351.76 g/mol, Purity >98%. PIP3/protein binding inhibitor. Specifically disrupts PIP3/Akt PH domain binding (IC 50 = 31 μM); suppresses PI3K-PDK1-Akt-dependent phosphorylation. Reduces cell viability and induces apoptosis in PTEN-deficient U87MG glioblastoma cells (IC 50 = 37 μM). 3,5-Dimethyl PIT-1 (ab120884) also available.
Key facts
CAS number:53501-41-0,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:351.76 g/mol,
Molecular formula:C14H10ClN3O4S,
Nature:Synthetic,
Solubility:Soluble in DMSO to 20 mg/mlSoluble in ethanol to 0.5 mg/ml,
Biological description:PIP3/protein binding inhibitor. Specifically disrupts PIP3/Akt PH domain binding (IC50 = 31 μM); suppresses PI3K-PDK1-Akt-dependent phosphorylation. Reduces cell viability and induces apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 μM). 3,5-Dimethyl PIT-1 (ab120884) also available.,
Canonical smiles:O=C(NC(NC1=C(O)C(CL)=CC([N+]([O-])=O)=C1)=S)C2=CC=CC=C2,
IUPAC Name:N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months