Abcam, ab120947, L-161,982, EP4 receptor antagonist

Size: 10mg / 50mg
MW 654.72 g/mol, Purity >98%. Potent EP 4 receptor antagonist, selective over all other prostanoid receptor family members (K i values for human receptors are 0.024 (EP 4 ), 0.71 (TP), 1.90 (EP 3 ), 5.10 (DP), 5.63 (FP), 6.74 (IP), 19 (EP 1 ) and 23 μM ( EP 2 )). Shows a variety of biological actions including suppression of PGE 2 stimulated bone formation, blocking of cell proliferation and also reverses anti-inflammatory action of PGE 2 .
Key facts
CAS number:147776-06-5,
Purity:>98%,
Molecular weight:654.72 g/mol,
Nature:Synthetic,
Solubility:Soluble in DMSO to 10 mM,
Biological description:Potent EP4 receptor antagonist, selective over all other prostanoid receptor family members (Ki values for human receptors are 0.024 (EP4), 0.71 (TP), 1.90 (EP3), 5.10 (DP), 5.63 (FP), 6.74 (IP), 19 (EP1) and 23 μM ( EP2)). Shows a variety of biological actions including suppression of PGE2 stimulated bone formation, blocking of cell proliferation and also reverses anti-inflammatory action of PGE2.,
Canonical smiles:CCCCC1NN(C(=O)N1CC1CCC(CC1)C1CCCCC1S(=O)(=O)NC(=O)C1SCCC1C)C1CCCCC1C(F)(F)F,
IUPAC Name:N-[[4'-[[3-Butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1'-biphenyl]-2-yl]sulfonyl]-3-methyl-2-thiophenecarboxamide

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months