Abcam, ab121202, Anti-FCGBP antibody

Size: 100µL
Rabbit Polyclonal FCGBP antibody. Suitable for IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human IgGFc-binding protein aa 250-450.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human IgGFc-binding protein aa 250-450. The exact immunogen used to generate this antibody is proprietary information.Q9Y6R7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FCGBP also known as IgGFc-binding protein is a large glycoprotein with an approximate mass of 540 kDa. It plays a mechanical role in binding immunoglobulin G Fc fragments which suggests possible involvement in the immune system. Researchers have observed its expression in various mucosal tissues including the intestinal tract and the airway epithelium. There it may interact with mucosal antibodies and contribute to the formation of protective barriers.
Biological function summary
The function of FCGBP involves interactions within the mucosal immune response. It forms complexes with mucins such as MUC2 facilitating the gel-like structure of mucus essential for barrier function. The protein helps in protecting tissues from pathogens and environmental insults through its role in stabilizing the mucus layer. Such interactions highlight its significance in maintaining mucosal immunity and homeostasis especially in environments exposed to external elements.
Pathways
FCGBP is essential in both the innate and adaptive immune pathways. In the mucosal immunity pathway it collaborates with mucins to regulate pathogen access to epithelial surfaces. Additionally its interactions with proteins like IgG provide a link to the immune system's antibody-mediated processes. Through these pathways FCGBP ensures the protection of mucosal surfaces from pathogenic invasion and supports immune surveillance.
FCGBP shows associations with conditions like inflammatory bowel disease (IBD) and cystic fibrosis. In IBD altered mucosal barrier function implicates FCGBP due to its role in mucus integrity. MUC2 abnormalities often accompany these diseases and show how disrupted interactions with FCGBP contribute to mucosal inflammation and barrier dysfunction. In cystic fibrosis faulty mucus barriers highlight the protein's importance in respiratory health connecting it to pulmonary conditions where disrupted mucus properties are common.