Abcam, ab121243, Anti-MTIF2 antibody

Size: 100µL
Rabbit Polyclonal MTIF2 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MTIF2 aa 450-650.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MTIF2 aa 450-650. The exact immunogen used to generate this antibody is proprietary information.P46199

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MTIF2 also known as mitochondrial translational initiation factor 2 plays an important role in mitochondrial protein synthesis. It functions as a GTPase that assists in forming the initiation complex for mitochondrial translation. MTIF2 has a molecular mass of around 78 kDa. Scientists have observed its expression predominantly in mitochondria-rich tissues such as muscle and liver highlighting its role in cellular energy production.
Biological function summary
MTIF2 is important for mitochondrial translation initiation making it an essential player in the synthesis of proteins encoded by the mitochondrial genome. It is part of the rescue and recycling phase of the translation mechanism and associates with the mitochondrial ribosome. MTIF2 helps in binding the initiator tRNA to the small ribosomal subunit in the presence of GTP ensuring accurate protein synthesis necessary for mitochondrial function.
Pathways
MTIF2 operates within the mitochondrial translation pathway which is integral for the production of proteins critical for the oxidative phosphorylation process. This process includes components like NADH dehydrogenase and cytochrome c oxidase subunits. MTIF2 interacts closely with other mitochondrial translation factors such as MTIF3 ensuring precise protein synthesis for energy production and cellular metabolism.
MTIF2 has been linked to mitochondrial disorders such as mitochondrial myopathy and encephalopathy resulting from defects in mitochondrial translation processes. These conditions often involve associated proteins like mitochondrial tRNA synthetases which play key roles alongside MTIF2. Such disorders are characterized by impaired energy production leading to symptoms affecting muscle and neurological functions reflecting the vital role of MTIF2 in maintaining normal mitochondrial operations.