Abcam, ab121362, Anti-TMEM25 antibody

Size: 100µL
Rabbit Polyclonal TMEM25 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TMEM25 aa 250 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TMEM25 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q86YD3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TMEM25 also known as Transmembrane Protein 25 functions as a transmembrane signaling receptor. It has a mass of approximately 60 kilodaltons. Expression of TMEM25 is mainly in the central nervous system including brain tissues. Additionally TMEM25 localizes in the plasma membrane indicating its potential role in cell signaling and communication.
Biological function summary
The role of TMEM25 includes involvement in cell adhesion and signal transduction processes. It does not appear to be part of any known complex directly. However it likely interacts with other membrane proteins and receptors to transmit signals across the cell membrane. TMEM25 may affect neuronal development and synaptic functions due to its high expression in neural tissues.
Pathways
TMEM25 participates in neurodevelopmental signaling pathways. It interacts within the cell adhesion molecule signaling pathway influencing neural connections and integrity. TMEM25 shares functional context with proteins such as CAMs (cell adhesion molecules) which are important for maintaining neuronal networks. It also contributes to the signal transduction pathways that control neuronal plasticity and responsiveness.
Researchers associate TMEM25 with certain neurodevelopmental and neurodegenerative conditions. It links to autism spectrum disorders due to its role in signal transduction and cell adhesion in neurons. Additionally altered expression of TMEM25 may contribute to Alzheimer's disease where disruptions in cell signaling and synaptic integrity are common. In these contexts TMEM25 might connect with proteins like APP (amyloid precursor protein) which is implicated in Alzheimer's disease.