Abcam, ab121365, Anti-GRAMD1C antibody

Size: 100µL
Rabbit Polyclonal GRAMD1C antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GRAMD1C aa 450-550.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human GRAMD1C aa 450-550. The exact immunogen used to generate this antibody is proprietary information.Q8IYS0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GRAM domain-containing 1C (GRAMD1C) is a protein involved in the mechanical process of cell organization and regulation. It is also known as Aster-C. GRAMD1C has a molecular weight of approximately 57 kDa. This protein is expressed in various tissues but shows higher expression levels in liver and testis. GRAMD1C contains a GRAM domain and a VASt domain that contribute to its role in lipid transfer and membrane binding processes.
Biological function summary
GRAMD1C plays a role in the transport and metabolism of sterols and phosphatidylserine. It does not function alone but is part of a larger complex that includes additional family members like GRAMD1A and GRAMD1B. By coordinating with these proteins GRAMD1C helps maintain lipid homeostasis in cells. These functions are essential for normal cellular processes and contribute to membrane dynamics and signaling.
Pathways
GRAMD1C impacts the cholesterol homeostasis pathway and the phosphatidylserine translocation pathway. In the cholesterol homeostasis pathway GRAMD1C works with other related proteins such as STARD4 to facilitate sterol transport within the cell. The phosphatidylserine translocation pathway benefits from GRAMD1C's involvement by positioning lipids correctly on the cell membrane helping to ensure proper signaling and cell survival functions.
GRAMD1C shows a relationship with metabolic disorders and liver-related diseases. Altered function or expression of GRAMD1C may contribute to conditions such as non-alcoholic fatty liver disease. Its connection with other proteins like GRAMD1A in lipid metabolism suggests that disruptions within this family could lead to metabolic syndrome. Understanding these relations helps identify potential therapeutic targets for these diseases.