Abcam, ab121394, Anti-RELL1 antibody

Size: 100µL
Rabbit Polyclonal RELL1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RELL1 aa 100 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RELL1 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8IUW5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RELL1 also known as RELT-like 1 is part of the tumor necrosis factor receptor (TNFR) superfamily. It plays a role in signal transduction specifically in mediating survival and apoptotic signals. The protein has a molecular weight of approximately 40 kDa. It is expressed in various tissues including the lung liver spleen and immune-related cells such as T and B lymphocytes.
Biological function summary
RELL1 contributes to immune system regulation by interacting with other TNFR family members and modulating signaling pathways that influence cell death and survival. It often engages in forming receptor-ligand complexes to execute its function. The protein's activity may affect processes such as inflammation and immune responses.
Pathways
The TNF signaling and NF-kappaB pathways are relevant to RELL1. These pathways are critical for transmitting signals that lead to either cell survival or apoptosis. RELL1 interacts with proteins such as TRAF2 and TRAF3 which are instrumental in mediating downstream signaling events within these pathways.
RELL1 has connections with autoimmune diseases and cancers. Its influence on immune cell regulation can contribute to autoimmune conditions by altering immune tolerance. Additionally aberrant signaling through pathways involving RELL1 can affect cell proliferation linking it to certain cancer types. The protein's interaction with TNFR family members like TNFR1 can exacerbate these conditions reflecting its potential importance in therapeutic targets.