Abcam, ab121488, Anti-TMEM45B antibody

Size: 100µL
Rabbit Polyclonal TMEM45B antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Transmembrane protein 45B aa 50-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Transmembrane protein 45B aa 50-100. The exact immunogen used to generate this antibody is proprietary information.Q96B21

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TMEM45B also known as Transmembrane Protein 45B is a protein encoded by the TMEM45B gene. It has a molecular mass of approximately 27 kDa. This protein is a multi-pass membrane protein implicated in cellular processes due to its location within the membrane. TMEM45B is expressed in various tissues including high expression in the liver kidney and certain brain regions indicating its diverse roles in different organ systems.
Biological function summary
TMEM45B plays a role in cellular homeostasis and signaling. This protein might interact with other transmembrane proteins to contribute to membrane dynamics and cellular communication. Although TMEM45B is not part of a well-defined protein complex its functional relevance is evident from expression studies and bioinformatics analysis. The precise biological mechanisms are still under investigation but roles in modulating cell-surface receptor activity have been suggested.
Pathways
TMEM45B is involved in pathways related to cell adhesion and signaling. It is implicated in the cell adhesion pathway connecting with proteins like integrins which are vital for cell attachment and migration. Moreover TMEM45B also participates in signaling pathways that regulate cellular growth where it interacts with growth factor receptors to influence cell proliferation. These connections highlight TMEM45B's role in maintaining cellular architecture and responding to environmental stimulations.
TMEM45B has a connection to cancer and metabolic disorders. Alterations in its expression or function can lead to aberrant cell growth linking it to tumorigenesis. Studies indicate potential interactions with proteins such as EGFR which is significantly involved in many cancers. Additionally TMEM45B is linked to insulin resistance affecting the metabolic pathway and contributing to disorders like type 2 diabetes. This association with metabolic and proliferative pathologies makes TMEM45B a target of interest for therapeutic interventions.