Abcam, ab121585, Anti-NYNRIN antibody

Size: 100µL
Rabbit Polyclonal NYNRIN antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human NYNRIN aa 1450-1650.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human NYNRIN aa 1450-1650. The exact immunogen used to generate this antibody is proprietary information.Q9P2P1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The NYNRIN protein also recognized as Human DNA-binding protein RYBP plays a significant mechanical role in the cellular environment. The molecular mass of NYNRIN is approximately 27 kDa. It is expressed in various tissues including the brain and heart indicating a possible wide-ranging impact across different organs. The protein carries out critical functions related to gene regulation due to its involvement with nucleic acids.
Biological function summary
NYNRIN contributes to key processes within cells such as transcription regulation and chromatin modification. Researchers have identified it as part of the Polycomb group (PcG) proteins which form complex structures like the Polycomb repressive complex 1 (PRC1). These complexes are essential in maintaining gene expression patterns during development ensuring proper cellular function and identity over an organism's lifetime.
Pathways
NYNRIN is closely tied with the Wnt signaling pathway and the ubiquitin-proteasome system. The protein interacts with other components within these pathways to mediate its effects on gene silencing and protein degradation. NYNRIN shows a relationship with proteins such as BMI1 which is an important member of the PRC1 complex playing a pivotal role in the epigenetic control of various signaling cascades influencing cell cycle dynamics and differentiation.
NYNRIN has implications in cancer and neurodegenerative conditions. Dysregulation of its function can lead to malfunction of PcG complexes linked to cancer progression and the disruption of developmental pathways. Studies highlight its connection with proteins like EZH2 another PcG component which associates with aggressive tumor types. Additionally alterations in NYNRIN expression have been observed in neurodegenerative diseases suggesting a role in maintaining neural cell homeostasis.