Abcam, ab121617, Anti-ARHGAP23 antibody

Size: 100µL
Rabbit Polyclonal ARHGAP23 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ARHGAP23 aa 500-600.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ARHGAP23 aa 500-600. The exact immunogen used to generate this antibody is proprietary information.Q9P227

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ARHGAP23 also known as Rho GTPase-activating protein 23 is a member of the RhoGAP family of proteins. It plays an important role in regulating Rho protein signaling by converting active GTP-bound Rho proteins into their inactive GDP-bound state. The molecular mass of ARHGAP23 is approximately 183 kDa. It is mainly expressed in various tissues including the brain and liver indicating its important role in cellular activities across different organ systems.
Biological function summary
ARHGAP23 acts as a critical regulator of cytoskeletal dynamics and cellular morphology. It functions as part of a complex that modulates actin filament organization which is essential for cell movement and proliferation. Through its interactions it influences the cellular response to external stimuli impacting processes such as cell migration and adhesion which are important in tissue development and repair.
Pathways
ARHGAP23 is a significant component of the Rho signaling pathway where it works to control cytoskeletal rearrangements. It interacts with other proteins like RhoA and Cdc42 coordinating their activity to ensure precise regulation of cytoskeletal structures. Additionally its involvement in the signaling cascade affects the MAPK pathway with implications for cellular growth and differentiation.
ARHGAP23 alterations can be associated with certain types of cancers and neurodegenerative disorders. Changes in its expression or function can disrupt normal cell-cell adhesion and cytoskeletal organization contributing to the progression of malignant tumors. In the context of neurodegeneration its interaction with proteins like Rac1 may influence neuronal survival and function potentially linking it to disorders such as Alzheimer's disease.