Abcam, ab121684, Anti-ANKFN1 antibody

Size: 100µL
Rabbit Polyclonal ANKFN1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ANKFN1 aa 300-450.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ANKFN1 aa 300-450. The exact immunogen used to generate this antibody is proprietary information.Q8N957

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ANKFN1 also known as Ankyrin Repeat and Fibronectin Type III Domain Containing 1 acts as an intracellular protein that plays roles in maintaining cell structure and signal transduction. ANKFN1 carries a molecular mass of approximately 67 kDa. Researchers find this protein expressed in various tissues with higher levels observed in the central nervous system and cardiac tissue.
Biological function summary
ANKFN1 interacts with proteins involved in cellular adhesion and motility. This protein may be part of larger complexes that include cytoskeletal elements suggesting a role in stabilizing cell architecture. Its ankyrin repeat domain facilitates protein-protein interactions which are necessary for transmitting signals across cellular membranes and within cells themselves.
Pathways
ANKFN1 contributes to cellular signaling and structural frameworks. It participates in pathways like the mitogen-activated protein kinase (MAPK) pathway which is significant for cell growth and differentiation. Through this pathway ANKFN1 interacts with other proteins like RAF and MEK aiding in the signal transduction process ensuring appropriate cellular responses to external stimuli.
ANKFN1 shows associations with conditions affecting the central nervous system and heart. Studies link alterations in ANKFN1 to neurodegenerative diseases and cardiomyopathies. Its interactions with proteins such as tau in neural tissues suggest a connection to tauopathies while in cardiac tissues misregulation of ANKFN1 may contribute to heart muscle disorders through altered protein interactions that impair normal cardiac function.