Abcam, ab121836, Anti-ENY2 antibody

Size: 100µL
Rabbit Polyclonal ENY2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ENY2 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ENY2 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q9NPA8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ENY2 also known as Enhancer of Yellow 2 acts as a vital component within certain transcription processes. With a molecular weight of approximately 14 kDa ENY2 associates closely with transcriptional regulation mechanisms. High expression levels occur in tissues where active transcription is prominent like liver and kidney. ENY2 influences the activity of various transcription complexes critical for gene expression.
Biological function summary
ENY2 facilitates dynamics within the transcription regulation landscape and participates as part of the TREX-2 complex. This complex plays an important role in coupling transcription and mRNA export. ENY2 contributes to stabilizing interactions between different elements of the transcriptional machinery promoting effective communication between nuclear processes. By participating in these activities ENY2 ensures adequate processing and shipping of mRNA from the nucleus to the cytoplasm.
Pathways
ENY2 influences the gene expression pathway specifically affecting transcription and mRNA export. ENY2's involvement in the transcription-coupled export pathway highlights its connectivity with proteins such as the THO complex and GANP. These interactions underline its role in coordinating the assembly and function of transcriptional machinery and proper gene expression and cellular operations.
ENY2 relates to certain types of cancer and transcription-related disorders. Abnormal expression or mutations within the ENY2-linked pathways correlate with tumorigenesis and cancer progression. Disruptions in ENY2 function can also associate with GANP impacting its role in proper gene regulation and stability. Consequently scrutinizing ENY2 may reveal significant insights into these conditions and potential therapeutic targets.