Abcam, ab121856, Anti-PRAX-1 antibody

Size: 100µL
Rabbit Polyclonal PRAX-1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TSPOAP1 aa 1150-1300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TSPOAP1 aa 1150-1300. The exact immunogen used to generate this antibody is proprietary information.O95153

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PRAX-1 also called Proline-Rich Anxious (PRAX) Protein 1 is a protein involved in neuronal signaling processes. Its molecular mass is approximately 28 kDa. The protein shows strong expression in the central nervous system notably within neurons. PRAX-1 has regions rich in proline which facilitates interactions with other proteins. These interactions hint that the protein could have multifunctional roles in cellular environments where it is expressed.
Biological function summary
PRAX-1 aids in the regulation of neuronal signal transduction mechanisms. It does not usually function as part of a large protein complex. It acts independently to influence synaptic functions and neural plasticity suggesting its role in adapting neuron signaling to various stimuli. This function is essential in maintaining healthy neuron communication and may impact learning and memory processes within the brain.
Pathways
PRAX-1 operates within the MAP kinase signaling cascade a pathway important for transmitting extracellular signals to elicit cellular responses. The intricate interaction with other signaling proteins such as Ras and ERK signifies PRAX-1's involvement in modulating these pathways. These connections position PRAX-1 as a potential regulator at multiple levels of cell signaling networks impacting various cellular responses.
PRAX-1 has links to anxious behavior which can arise from abnormal neuronal signaling. Researchers connect dysfunction in this protein with anxiety-related conditions. Furthermore PRAX-1 interacts with GABAergic signaling involving GABA receptors which play a role in anxiety disorders. The protein’s altered function may therefore contribute significantly to the pathophysiology of these mental health disorders.