Abcam, ab121960, Anti-HINT3 antibody

Size: 100µL
Rabbit Polyclonal HINT3 antibody. Suitable for IHC-P, ICC, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human HINT3 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human HINT3 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q9NQE9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HINT3 also known as Histidine Triad Nucleotide Binding Protein 3 is a protein encoded by the human HINT3 gene. This protein has a molecular mass of approximately 16 kDa. Mechanically HINT3 functions by binding nucleotides through the histidine triad motif which typically involves AMP and other similar molecules. The expression of HINT3 occurs widely with significant levels found in human brain tissues liver and various other organs which suggests it plays roles in multiple cellular processes.
Biological function summary
The HINT3 protein operates within cells to regulate nucleotide metabolism with implications in various enzymatic activities. It often forms part of larger protein complexes interacting with other nucleotide-binding proteins to execute its functions. Research indicates its involvement in cellular energy homeostasis suggesting a broad impact on maintaining cellular functions by controlling nucleotide turnover and recycling.
Pathways
HINT3 connects to key metabolic pathways like the purine nucleotide biosynthesis and salvage pathways. In these pathways its interactions with related proteins such as IMPDH (Inosine Monophosphate Dehydrogenase) and GMPS (Guanosine Monophosphate Synthetase) highlight its influence in maintaining the balance of nucleotides. These pathways ensure the availability and proper use of nucleotides necessary for DNA and RNA synthesis.
For instance alterations in the expression or functionality of HINT3 might contribute to tumor development as cancer cells often show disrupted nucleotide metabolism. Related proteins such as IMPDH have roles in oncogenesis and their activities can be affected by changes in HINT3 expression or function. HINT3 also shows associations with neurological disorders which are often tied to its expression in brain tissues impacting neuronal nucleotide balance and signaling pathways.